Paul When a child is diagnosed with cancer or a blood disease, it impacts the entire family. 17, p 8 Pediatric Normal Range Study (1995) Children’s Hospitals, Minneapolis and St. With that, patients with a MPV between 9.7 fL and 12.8 fL are still deemed to be in a good. As it is hard to imagine that minute of an amount, the normal MPV should range from 7.5 fL to 11.5 fL. One fL is equal to the metric unit of one quadrillionth of a liter. The new definitions will render the diagnoses of neonatal thrombocytopenia and thrombocytosis less commonly than when the old definitions were used, because the new ranges are wider than 150,000 microl(-1) to 450,000 microl(-1). Pediatric Normal Ranges (1995) Children’s Hospital of Buffalo, Coulter VIEWPOINT, No. What Is Normal MPV Range The volume of platelets is measured in femtoliters, or fL. Expected values differ substantially from the 150,000 microl(-1) to 450,000 microl(-1) range previously used to define neonatal thrombocytopenia and thrombocytosis. The figures herein describe reference ranges for platelet counts and MPV determinations of neonates at various gestational ages during their first 90 days. The upper limit of expected counts (95th percentile) during these peaks were as high as 750,000 microl(-1). Advancing postnatal age had a significant effect on platelet counts during the first 9 weeks, the counts fit a sinusoidal pattern with two peaks one at 2 to 3 weeks and a second at 6 to 7 weeks. In those born < or =32 weeks gestation, the lower reference range (5th percentile) was 104,200 microl(-1), but it was 123,100 microl(-1) in late-preterm and -term neonates. The first platelet counts obtained in the first 3 days of life, increased over the range of 22 to 42 weeks gestation. Platelet counts were obtained between the first and the 90th day after birth, from 47,291 neonates delivered at 22 to 42 weeks gestation. We derived new neonatal reference ranges for platelet counts and mean platelet volume (MPV) measurements using electronic data accumulated during a recent 6-year period from a multihospital healthcare system. However, the published reference ranges for platelet counts in neonates may be imprecise, as they were generated from relatively small sample sizes and compiled before modern platelet enumeration methods. Identifying a platelet count as abnormal (thrombocytopenia or thrombocytosis) can facilitate recognizing various disease states.
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